The questions arise here, how enzymes are able to accomplish such effective catalysis and why thermodynamically favorable reactions do not proceed ob their own at relatively rapid rates in the absence of enzymes?
Chemical transformation requires that certain covalent bonds be broken within the reactants. To do so the reactants much contain sufficient kinetic energy ( energy of motion) to overcome a barrier called Energy of Activation or Activation Energy. The important role play by enzymes during reactions is that they lower down the activation energy of reaction. The enzymes reacts with the energy rich and energy poor molecules which form an intermediate complex. This complex again break into product and enzymes. If activation energy of formation of this complex is low, many molecules can react and participate in reaction. In this way activation energy is lowered by the enzymes but in this action equilibrium (ration of concentration of reactants and product) is never altered
Chemical transformation requires that certain covalent bonds be broken within the reactants. To do so the reactants much contain sufficient kinetic energy ( energy of motion) to overcome a barrier called Energy of Activation or Activation Energy. The important role play by enzymes during reactions is that they lower down the activation energy of reaction. The enzymes reacts with the energy rich and energy poor molecules which form an intermediate complex. This complex again break into product and enzymes. If activation energy of formation of this complex is low, many molecules can react and participate in reaction. In this way activation energy is lowered by the enzymes but in this action equilibrium (ration of concentration of reactants and product) is never altered
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