The electron microscope reveals a complex network of channels , the endoplasmic reticulum (ER) which extends from from plasma membrane to the the nuclear membrane. It is an elaborate, tube, like system of lipoprotein. There are two types of endoplasmic reticulum : (a) A granulated or Smooth endoplasmic reticulum (SER) and (b) Rough or granulated endoplasmic reticulum (RER). Smooth endoplasmic reticulum is not associated with ribosomes. It is found in storing producing cells like adipose cells (fat cells), interstitial cells, glycogen storing cells (liver) and the muscle cells. Rough or granular endoplasmic reticulum (RER), is heavily coated with ribosomes on its outer surface towards cytoplasmic surface. Rough ER, occurs mostly in protein synthesizing cells. Such as those of the mammalian salivary glands and pancreas. Although most cells contain both rough and smooth ER but they vary from cell to cell.
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